The ability to use drugs safely and effectively is a defining characteristic of a good doctor. Th is ability is predicated upon an up-to-date knowledge of the ever-expanding pharmacopeia available to modern clinicians. In recent years the advent of translational and stratified approaches to the development of new medicines has accelerated the pace of change and resulted in a profusion of new knowledge across a wide range of therapeutic areas.
Th e extensive changes made to the text of this the ninth edition of Clinical Pharmacology and Th erapeutics Lecture Notes reflect the enormous progress made in recent years. The new edition has been extensively revised and updated with significantly expanded sections covering areas which are developing rapidly such as immunopharmacology and cancer therapeutics. A particular emphasis has been placed upon practical aspects and clinical relevance throughout each chapter. Although the content of the text has been revised and refreshed, the objective of this book remains as set out in the preface to its first edition more than 30 years ago: to provide a brief, clearly written and up-to-date review of clinical pharmacology. As in earlier editions we have not attempted to be comprehensive, but have tried to emphasise the principles of clinical pharmacology, and topics which are of particular clinical importance.